CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading
Proceedings of the National Academy of Sciences, Volume 122, Issue 2, January 2025. SignificanceMajor histocompatibility complex (MHC-I) proteins select repertoires of epitopic peptides to display on the cell surface for T cell surveillance, against a vast background of possible decoys. However, the molecular mechanism of this selection…
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