CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading

Proceedings of the National Academy of Sciences, Volume 122, Issue 2, January 2025.
SignificanceMajor histocompatibility complex (MHC-I) proteins select repertoires of epitopic peptides to display on the cell surface for T cell surveillance, against a vast background of possible decoys. However, the molecular mechanism of this selection…
Read More

Leave a Reply

Your email address will not be published. Required fields are marked *

This website is using cookies to improve the user-friendliness. You agree by using the website further.

Privacy policy
Skip to content