Potassium-sensitive loss of muscle force in the setting of reduced inward rectifier K+ current: Implications for Andersen–Tawil syndrome

Proceedings of the National Academy of Sciences, Volume 122, Issue 13, April 2025. SignificanceLoss-of-function mutations of the Kir2.1 K+channel subunit cause a triad of periodic paralysis, cardiac arrhythmia, and skeletal anomalies in the Andersen–Tawil syndrome. As with other forms of periodic paralysis, changes in K+may trigger …

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