Broad beta-CoV immunity and transmission blockade by a single-dose live-attenuated vaccine with atypical codon usage
Proceedings of the National Academy of Sciences, Volume 123, Issue 4, January 2026. SignificanceWe report a rational-designed live-attenuated beta-coronavirus vaccine (cb1) with altered codon usage bias. cb1 is a highly attenuated yet immunologically potent vaccine, capable of eliciting both systemic and mucosal immune responses, …
Read more