Rheumatologists Concerned by Broad Long COVID Definition

A group of researchers in rheumatology has raised concerns about the 2024 definition of long COVID from the National Academies of Science, Engineering, and Medicine (NASEM), citing both lack of specificity and the inclusion of autoimmune rheumatic diseases despite inconsistent evidence that they’re linked to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection…

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Structural insights into the role of reduced cysteine residues in SOD1 amyloid filament formation

Proceedings of the National Academy of Sciences, Volume 122, Issue 5, February 2025. SignificanceAlthough Cu/Zn superoxide dismutase (SOD1) primarily detoxifies cells by scavengingsuperoxide radical (O2•-), it also contributes to amyotrophic lateral sclerosis (ALS) by generating unusual amyloid filaments. We found that mutant SOD1 …

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MI Care Varies by Sex Even Though Death Risk Similar

TOPLINE: Patients with ST-segment elevation myocardial infarction (STEMI), classified as having MI with nonobstructive coronary arteries (MINOCA) or MINOCA mimickers, exhibit sex-based differences in prevalence and treatment, but the 5-year mortality risk remains similar between sexes after adjusting for confounders. METHODOLOGY: Researchers analyzed data of 8560 patients with STEMI prospectively enrolled in a consortium in

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