Structural insights into the role of reduced cysteine residues in SOD1 amyloid filament formation

Proceedings of the National Academy of Sciences, Volume 122, Issue 5, February 2025.
SignificanceAlthough Cu/Zn superoxide dismutase (SOD1) primarily detoxifies cells by scavengingsuperoxide radical (O2•-), it also contributes to amyotrophic lateral sclerosis (ALS) by generating unusual amyloid filaments. We found that mutant SOD1 …
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